Endocrine Abstracts

Introduction: High levels of autoantibodies to glutamic acid decarboxylase (GAD-Ab) have been described in multiple conditions such as: stiff-man syndrome, type 1 diabetes mellitus, latent autoimmune diabetes in adults (LADA), patients with auto-immune polyglandular failure and etc. In addition, some of the patients with progressive cerebellar ataxia show high titer of GAD-Ab, it may play a critical role in its development, as these antibodies are involved in the pathogenesis ...

Introduction: Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism results in thermolabile, reduced functioning enzyme and predicts hyperhomocisteinemia and altered DNA methylation. On the other hand, several studies indicated a higher plasma homocysteine (Hcy) levels in patients with primary hypothyroidism than in healthy, euthyroid individuals, including some experimental studies that indicated decreased MTHFR activity in hypothyroid patients. We cond...